Image quality assessment methods are used in different image processing applications. Among them, image compression and image super-resolution can be mentioned in wireless capsule endoscopy (WCE) applications. The existing image compression algorithms for WCE employ the generalpurpose image quality assessment (IQA) methods to evaluate the quality of the compressed image. Due to the specific nature of the images captured by WCE, the general-purpose IQA methods are not optimal and give less correlated results to that of subjective IQA (visual perception). This paper presents improved image quality assessment techniques for wireless capsule endoscopy applications. The proposed objective IQA methods are obtained by modifying the existing full-reference image quality assessment techniques. The modification is done by excluding the noninformative regions, in endoscopic images, in the computation of IQA metrics. The experimental results demonstrate that the proposed IQA method gives an improved peak signal-tonoise ratio (PSNR) and structural similarity index (SSIM). The proposed image quality assessment methods are more reliable for compressed endoscopic capsule images.